madresota Share definition Flag (Mexican) adj. - Slang word in spanish used to describe an extremely massive object/person/thing/animal/etc. (Students looking at hot ass teacher) Mira las madresotas que tiene esa maestra. madresota by freestyle760 March 10, 2009 0 0 Get merch Get the madresota mug. Buy Now — $32.95 See more merch