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1) the muscles that flex in the back of your head when you laugh.
2) uncontrollable laughter caused by a nice fatty boombatty blunt.
(guy 1): yo man i'm feelin it.
(guy 2): yo man... me too.
(guy 1): HAHAHAHAHAHAHAHAHAHAHAAAAAAHAHAHAHAHAHAHAHAAAAHAHAHAHAAAA.
(guy 2): yo this nigga guy 1 got the ganoobies.
ganoobies by waudi c. wilkins August 5, 2003
Related Words

Gabookie 

Something your friends says to show they’re a dry texter or just the driest way to end a conversation
Friend 1: Hey what’s up
Friend 2: Gabookie
Gabookie by Dangerous golf ball January 3, 2021
also, gannobied or ganoobified.
the state of being high and laughing uncontrolably.
"I smoked so much weed last nite that i had the ganoobies!
" You are hella ganoobied, man!"
"Let's go get ganoobified!"
ganoobies by jizosh420 March 30, 2004

Ganoobie 

1. The first person that laughs uncontrollably amongst friends when toking on the peace pipe. 2. An alternative band that when listened to high will chill you the fuck out and then give you the ganoobies. 3. A fun word to say in various speeds and accents.
1. Yo Marco, calm down ... your laugh sounds like a constipated hyena. Your such a Ganoobie. 2. I love this song from Ganoobie. 3. Gaaanooooobbbiiieee, Ganoobie, Gaaannnnnnnoooooooooobbbbbbbiiiiiieeeee.
Ganoobie by Wilhelm Yell June 13, 2018
GNOOKIE: FEMALE GENTIALS OFTEN TIGHT AND GUSHY ASWELL CLEAN
DILLON: IM CRAVING GNOOKIE MARIO:I need gushy gnookie cookies
gnookie by pa libstu May 13, 2023