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It is short for different but it can be used as an noun, adjective, or verb. It’s meaning can change and has to be interpreted with context.
“Damn, LeBron James is so good at basketball. He is deefér.”

“Hey I’m thirsty, can you pass me that deefér.”

I’m tired I need to go deefér”
Deefér by NNNDeefér September 5, 2019
Related Words

Deefer Douchebag 

Someone exhibiting the qualities of a pansy, whiny ass bitch that thinks they are sweet at everything; Pretends to have many friends, but is unanimously hated.
"Man I hate that deefer douchebag. He really takes it hard in the ass."
Synonim for something that went wrong or is messed up. Something that is fucked.
When you get a virus on your computer, you can say that your computer is deefed.

There are various alterations to the word. You can simply say for example, "Computer deefed," when you need to say that you're computer is fucked.

Originated in Allentown, PA.
deefed by Robbit September 3, 2005

Dudefest 

Dudefest is the best Metal/Hardcore/Grindcore/Crust/Punk/Powerviolence/Doom/Sludge fest in the U.S. It has been held every summer since it's inception in 2003 in the city of Indianopolis in the state of Indiana. Some bands who have played over the past few years include: Pig Destroyer, Iron Lung, Genghis Tron, Kylesa, Hewhocorrupts, Skeletonwitch, Insect Warfare, Sweet Cobra, Torche and more.
Dude, let's fucking RAGE @ Dudefest!!!!
Dudefest by Rage On June 27, 2008
The name of my badass dog
Deefer by sephgordgon January 27, 2010
The fabled male equivalent of a 'queef'. Air trapped inside the male urethra, usually during/after oral sex, released in a flatulent like manner. They are odorless and are viewed as an embarrassing bodily function.

Derivatives:
* dueefed
* dueefing
"While receiving oral, bill dueefed by accident."
dueef by rizla5 June 16, 2009