Usually a business prospect that you are thinking about doing business with then after some insightful thinking you disqualify them before even discussing business matters with them.
Could also be a potential boyfriend or girlfriend whom you like then before you even approach him/her you find out something awful about him/her that you cannot stand, you automatically disqualify them from being your boyfriend or girlfriend before you even talk to him/her.
John: " Look at that girl, isn't she hot?! I'd make her my wife."
James: " Yeah she is hot. You don't know Mary? She used to be a man then dated a rich guy who paid for her sex change."
John: What? For real? She is pre-disqualified then!
Ruler of Lake Titicaca. Rumored to have a bunghole that gets very angry if it does not receive toilet paper. Cornholio the Great is often seen walking around with his shirt over his head and his hands in the air, chanting songs about his power, and his bunghole.
"I am Cornholio! You do not want to face the wrath of my bunghole, for I need TP!"
Butthead: Shut up, Beavis! (uh huh huh huh)
Beavis: Um, okay. (heh heh heh heh).