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Doctor of Osteopathic Medicine
Person A: "Are you doctor...an M.D.?"
Person B: "Yes, I'm a doctor, but I'm a D.O.!"
D.O. by ctak July 16, 2006
This usually means Depression and Obsession like the song “Depression & Obsession” in the XXXTentacion album “17”
d&o by Youngdaggerdiiiiick January 4, 2018
To punch someone excessively hard, breaking the top of their jaw with one swift move.
Kyle: *Punch to face*

Devin: *Face broken*

Crowd: "yo he got D.O.'d"
D.O. by spiderdude9 May 7, 2011
a :o with a hat on
(also q:o hat backwards)
Hey I'm cool i have a hat d:o
d:o by Ritalin January 5, 2004
1. go crazy, to fight

2. to fuck a sexy female without her being a girlfriend

3. beat to death without a weapon (man-slaughter)
1. that girl went D.O. in the classroom

2. later on I'm going to take her to my house D.O. her

3. he got into a fight with his homie and straight D.Oed him
D.O. by 7~4~4 June 24, 2009
1. verb, D.O. = "douche out" (circa 1967-8) - to become intoxicated to the point of passing out.. 2)noun, D.O. - a place or party where such intoxications occur 3) adjective - incapacitated lethargic, stuperous
Example: No, man. I'm just gonna sit 'round the house and D.O. with Valery or Xandy.

Hey man, you wanna get D.O.'d with us?

I'm too D.O.'d to drive.

I dunno, I Haven't gotten D.O.'d in almost a month. I'd better n.... Oh, what the hell.

This is gonna be a classic D.O.!
D.O. by pygmy71 November 17, 2004