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Literal translation is your co-mother. Typically reserved to identify someone who has a special shared responsibility with you, most commonly in raising a child. Most often in cases where the woman is the person you selected to be the godmother of your child.
Hi comadre, can you take Martin to Sunday school? I will be at an event and I can't take him.
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Litteraly is your children's godmother in spanish. But it's a sarcastic way to say buddy to a female when you're making fun of her. (compadre for males).
comadre by Mend.ozae May 1, 2008

Comardelle 

The most amazing, and mispronounced, last name in the world. Common in people who live "down the bayou" or on the Westbank in Nawlins. Usually pronounced as "Carmadelle" or "ComARdellie."
Person 1: Hey, what was that chick's last name? She lived on the West Bank?

Person 2: Oh, Comardelle. She's pretty fly.
1. godfather
2. a close friend
3. a classmate
4. a companion in war
mi compadre murio el sabado pasado en iraq.
los compadres duermien durante el clase.
compadre by CardPenComic December 1, 2006

Las Comadres 

This Mexican term a group of girls call themselves who are very close with one another, can joke around with one another, laugh like donkeys at almost anything, make fun of everything, spill tea all time, and are Mexican. They really don’t care what other people think. They are very smart but also very retarted. They have many inside jokes and text each other basically 24/7. They’ve been through many hardships and challenges but have survived together. Mainly through texting each other the answers on homework. But that’s what a comadre is. They will sacrifice everything just to help one and another and be there for one another. You can do anything with Las Comadres. They are completely insane. They are your best friends. Las Comadres is the name of your best friend group and your group chat. Also there is a member of the group who sends memes a lot to keep things interesting.シ
Crusty, Dusty, and Ricky call themselves Las Comadres.
Las Comadres by Ricky シ August 1, 2019

comaderious 

When someone makes everybody laugh at something that is not funny what so ever.
Idk why tilly is so comaderious her jokes are terrible!
comaderious by jovi the savage February 24, 2017
A male sex god. Usually found with a herd of women trailing behind him waiting to receive his seed. Muscular, good looking, and intelligent, he can win ANY woman over.
"Fuck yes! I just got laid by a total Comandre!"
Comandre by caramia May 8, 2009