Zempie Share definition Flag Someone who is on ozempic or some other anti-obesity medication and has undergone a dramatic weight loss in a relatively short amount of time. Whoa have you seen Sabrina lately? She lost 40 pounds in two months! She's a total Zempie. Zempie by B-Rain1346 September 7, 2025 0 0 Get merch Get the Zempie mug. Buy Now — $32.95 See more merch