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It simply means.

WHAT THE F*CK ARE YOU ON?

Say it to someone who says something completely f*cked up...

Or someone on drugs, and you really want to know, what the hell they are smoking.
GUY#1: I think I just saw a purple elephant drinking my beer in the kitchen...

Guy#2: Dude, wtfruo?
WTFRUO by claudzxrawr January 20, 2010
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Walsh: "Dude, Bruce is hitting on twelve-year olds again."
Dave: "Bruce, WTFRUD???"
WTFRUD by SoyTuPapa January 20, 2009
Related Words

wtfruwa? 

Abbreviation for: What The Fuck R U Wanking About?
Can be used in multiple forms of the human language
eg1) Person 1: Hey! Wtfruwa?
Person 2: Keira Knightly
Person 1: Sweet...

eg2) (Instead of "What the hell are you on about?")
Person 1: I am a bannana
Person 2: Wtfruwa?

eg3) (As a form of "Whats up?")
Person 1: Hey, wtfruwa?
Person 2: Not much
wtfruwa? by Pineapple Man September 19, 2006
person 1 (sends person 2 a text): 'wtfru??'
person 2(replies): sry i'm running rlly l8!!
wtfru by cwistian4lyf October 21, 2008

wtfru doin

Robby tried to pinch Jenna's tight ass. Then Jenna shrieked out, "WTFRU DOIN??!!"
wtfru doin by Melissa (MAB) October 28, 2007
Pat: Did see all those pretty sounds?

Mary J: WTFRUON?
wtfruon by notanoob92 March 20, 2010

WTFRUDMF?! 

"What the fuck are you doing mother fucker?" Similar to asking the question "wtfrud" but conveys more attitude and excitement. One might use this when setting up a night of heavy drinking.
Jack: wtfrud?
Bill: Idk.

vs.

Jack: WTFRUDMF?!
Bill: NOTHING! LETS DRINK BEER!!!
WTFRUDMF?! by HankStain May 3, 2011