*Spoiler alert*
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From the series Jojo's Bizarre Adventure, it was Joseph Joestar crying out Caesar Zeppeli's name after witnessing his death from Wamuu as he gives his energy to Jojo. In the Japanese version of the anime, it sounds like "SHIZAAAA"! It also in the Heritage for the Future game, though it is infamous just like in the anime.
Typical italian slang expression, it could assume different meanings in different regions. Predominantly used in Rome (Lazio) to manifest complete indifference regarding a certain issue. In other regions (such as Emilia-Romagna) it is generally used to express rather opposite feelings, such as astonishment or stupefaction.
Guy from Lombardia: "Amici, devo darvi una triste notizia. Silvio Berlusconi è morto la scorsa notte" ("Dear friends, I am sad to announce that Silvio Berlusconi died last night")
Guy from Emilia-Romagna: Sticazzi! Era ora! (Really? It was high time!)
Guy from Lazio: E sticazzi! (I don't give a fuck!)