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Relating to both males and females, to say someone is or has a Pizza Pus is someone who has super bad acne. This is so severe and nasty that it makes their face resemble a pizza.

Pus in this case means face, see pus/puss and also pus/puss that would come from spots/zits. The sheer amount of lumpy puss filled spots/zits look like cheese, the redness of the skin resembles tomato.

Especially bad cases may be topped with pepperoni. This will be like a large scab or perhaps mutated spot!
He had a total pizza pus, he needed help as he was getting no lady love.
by papastilto September 12, 2008
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