lolsies is a swell abbrevation for the average boring "LOL" response. If this swell abbrevation is used it means that it iseven more funnier than just the average "LOL".
My mother just farted when she leaned over to pick up her purse at Costco, LOLsies!!!
A variation of lol. Lolshisoym stands for "laughed out loud so hard I shit on your mother". Or, in other words, an expression of an example in which one laughs extremely hard.
"Dude, I just took a slam on the boss' secretarie's desk!!"