1) To be in a state of euphoria, induced by simply being alive. This definition is the official definition.
Alternately,
2) To be in a state of euphoria, induced by, but not limited to, a) the use of narcotics, legal or illegal; b) the consumption of alcoholic beverages; c) being in the presence of an extraordinarily attractive member of the opposite sex.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.