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fo' shizzle my wizzle 

"fo shizzle ma wizzle" is a bastardization of "fo' sheezy mah weezy" which is a bastardization of "for sure mah wigga" which is a bastdardization of "I concur with you whole heartedly my friend who wishes he was an African american brother"

fo' shizzle my wizzle 

For sure, my wigga.
(Certainly, my white counterpart)
Nathan: Let's be off to purchase goods.
Vincent: Fo' shizzle my wizzle!
Nathan: I beg your pardon?

fo shizzle my wizzle 

it means i concur whole heartedly with you my white african american sista or brother!

fo shizzle my wizzle 

eminem: fo shizzle my wizzle this is the plot, listen up, you pencils forgot, slizzle does not give a fuck!!!!