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Literally meaning yes. A ghetto slang term derived from 'for sure, my nigger'.

Also. Fo' shizzle my nizzle.
Also. Fo' shizzle mah nizzle.
You got AIDS?
Fo' shizzle my nizzo!
by Lexicon Master September 15, 2003
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2
Idiomatically translated: This is for sure-as in one would know this fact to be true.

Literally translated: FOR SURE MY NIG*A
TYRONE: Did you pass that difficult biology class at Harvard last semester?
KEYSHAWN: "fo shizzle my nizzo"--- Of course I passed the class with flying colors only to affirm my position on the Dean's List. How could you make such a ridiculous inquiry as to question my unlimited abilities?
by \'YO MAMA\' September 04, 2003
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3
A dazzled up way of saying "for sure my nigger" Originally used by african americans such as: Snoop Dogg and Jay-Z but over-taken by wiggers such as Justin Timberlake because of it's easy-speaking nature.
"Fo shizzle my nizzo! Dirty Pop sure was a great N*Sync hit!"
by Kristen December 01, 2003
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5
Explicit. An ebonic version of the phrase: For sure, my nigger. Used as a means of assent or agreement with a trusted companion.
Negro 1: Yo' wanna party wit' me?
Negro 2: Fo shizzle my nizzo
by Azmodeus September 17, 2003
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7
a play on the words within the phrase:
"for sure my nigger"
used in the context of agreement to any subject or activity
by hiphopablopshop September 15, 2003
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