fuckshizzle Share definition Flag A combination of both "fuck" and "shizzle" usually used to determine a horrible tragedy. It has a nifty ring to it. Oh FUCKSHIZZLE my girl just got pregnant, with another fucker! fuckshizzle by Fucking Cooler Than You May 10, 2006 0 0 Get merch Get the fuckshizzle mug. Buy Now — $32.95 See more merch