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To get beaten up or physically assaulted, particularly by a large gang of men.
"Yo, is that man tryna catch a duffice?"

"Man's tryna catch a duffice, eh?"

"We're about to pull up on him with the duffice!"
Duffice by sasan July 5, 2021
Words you can keep
Go hard, get retarded, dumb, any dude that steps up gets messed up
I go duffie.
Duffie by 23565 August 18, 2009
Duffie is a very loyal girl. If she falls in love with you, she'll never cheat on you. She's usually a bit of a tomboy, but very pretty.
She also has a good sense of humor and can be very sarcastic. Duffie is nearly perfect.
''I made Duffie my girlfriend.''

''Wow, good job! You'll be happy together!''
Duffie by grandpajoe November 18, 2013
Pathological liar. 98% of them are fluffy, the other 2% are fucking insane
She just duffied right to my face
Duffie by Frankie is a whore February 22, 2017
When someone is drunk beyond belief. Drunk to the point where homo-sexual behaviour is as standard as breathing. Licking somebody's face is more appropriate than hand shaking.
'He's completely wasted!' 'No.... He's worse. He's duffied'
Duffied by panda88888 January 9, 2010
Duffie is the Squad,Fam,ect but if a nigga try us we gonna beat that ass like a thanksgiving turkey
Duffie squad go hard
Duffie by DuffieGirlKay August 17, 2016

Duffication 

When railing a girl doggy style a man places two fingers in the females asshole. Once the fingers are inserted into the asshole the male attempts to use those fingers to masturbate himself through her asshole. The name is mixture of defication and masturbation.
Man I tried to give her the duffication but when I tried to get that second finger in she got pissed.
Duffication by Duffman81221 January 7, 2014
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