Slang Jon Stewart often uses for the flu or common cold.

Based on the way he pronounces it (tongue-in-cheek Godfather character accent) it's probably the plural form of the Italian word 'bubbone,' a swollen lymph node characteristic of bubonic plague. It probably developed as slang for an infection because bubonic plague is so infectious. Stewart probably picked it up growing up in the NJ/NY area.

"I have the bubons again. It's the second time in three months. Let me say this to anybody out there with children at home: buy an autoclave."

Jon Stewart
The Daily Show
February 22, 2011

Bubons by TDSFan123 March 12, 2011

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Bubonic Plague

Bubonic Plague is a contagious, often fatal epidemic disease which killed a third (50 Millon) of the world's population of Europeans and Asians in the 1430's. The bubonic plague is caused by the bacterium Yersinia pestis, transmitted from person to person, a bite of a flea from an infected host, and a bite from an infected rat.It is characterized by chills, fever, vomiting, bloody semen, diarrhea, the formation of buboes, inflamed lymph nodes (around armpits, neck, and groin), pain areas in the abdomen or muscles, coughing blood, the whole body would feel fever, chills, fatigue, or malaise, Gastrointestinal (nausea, vomiting, and diarrhea), and commonly, bleeding, delirium, headache, phlegm, shortness of breath, or swollen and tender lymph node.

The Bubonic Plague is a virus

Bubonic Plague by TF2 Fan April 1, 2017

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