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In Texas Hold'Em, it is commonly referred to when holding a King and an Ace. It is called such because it is a sweet, sweet hand, but can cause a bit of a toothache.
"Whoa Burt, I just ran my Big Sugar into pocket Aces! I was sure I had the best hand!"

"That Donk had a 25 against my Big Sugar!"
by HMFD November 08, 2007
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