Having a belly full of beer and a mind that's just as liquid. Being drunk on beer and stupid at the same time.
Bob was so beered-up that he tripped on his own feet and fell face-first into the fireplace while laughing as if his actions were excellententertainment.
1) Man, afta the mofo got hit by da car, his arm was all beefed up.
2) Oh yeah. This beer be all that, homie. I feel kinda beefed up. Know what I thought I meant I said?