yossup Share definition Flag The contraction of yo and wassup! usually used by two non-black people trying to sound nigga-cool. to save time and energy by saying hi and asking how are you at the same time. Dick : hey , haven't seen you for some time!Jerry: Yossup! (hey man, what brought you here? how are you? - in a nutshell) yossup by dcdarren February 24, 2010 Get the yossup mug.