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The contraction of yo and wassup! usually used by two non-black people trying to sound nigga-cool. to save time and energy by saying hi and asking how are you at the same time.
Dick : hey , haven't seen you for some time!

Jerry: Yossup! (hey man, what brought you here? how are you? - in a nutshell)
yossup by dcdarren February 24, 2010
Related Words

yosupohman 

Hey! Yo Sup! (*spills coffee) OH MAN! (yosupohman)
yosupohman by G-NOOB-IRL March 9, 2021
Yosup is the word all the cool kids use as a greeting.
Its a shorter way of saying "Yo, what's up?"
Person 1: YOSUP!
Person 2: Nothing much.
Yosup by Justin June 18, 2006
yossup homie
yossup by yeLLoJellO May 8, 2004

yooupiss 

yooupiss is amazing and always makes me smile <3
“have you met yooupiss?”

“no who is that”

the most stunning person in the world <3”
yooupiss by hornyemokid <3 September 27, 2021