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An exclamation of surprise, wonder, excitement, pleasure, etc. Originates from the tv show Home Movies and was used frequently by the character Jason in the episode Definite Possible Murder.
See Home Movies
Jason: Yeah it's a little stuffy in here. Wee-ow!

Brendon: Who moves furniture at 3 o'clock in the morning? Wee-ow!
by mikeiscooler June 08, 2009
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