when you've been up for forever on meth and are starting to trip hardcore - ie, when your face is beginning to become one giant open bleeding sore from picking at it.
"damn, i am so twacked out, i plucked until i dont have any eyebrows left."
"your pupils are so big you dont have any color in them - you'rehella twacked out."
"for the last time, that is a MINIVAN, not the FBI - quit getting so damned twacked out!"
When you're really high on meth or when you've been awake so long smoking dope that you're totally outta there! My friend was so twacked out on dope he thought that I was a cop.
I can't understand what the fuck you're saying cuz you're talking 100mph you're so twacked out.
I was so twacked out I thought there were undercover narcotics agents in the van parked across the street.
Being twacked out is when you're on tweak and you're freaking out. Tweak is also known as ice, glass, crank, or most commonly, crystal methamphetamine.
Person A: "Dude, chill out!"
Person B: "Man, I'm totallytwacked out." (Sitting there, picking at his skin/looking out the blinds/rocking back and forth)
12 step recovery jargon referring to someone new who talks about how great life is, now that they'resober. Usually meaning that the person is out of touch with reality.
The new guy seems pretty happy for a dude who has no job, no money and no family. He must be on a pink cloud.