when you've been up for forever on meth and are starting to triphardcore - ie, when your face is beginning to become one giant open bleeding sore from picking at it.
"damn, i am so twacked out, i plucked until i dont have any eyebrows left."
"your pupils are so big you dont have any color in them - you're hella twacked out."
"for the last time, that is a MINIVAN, not the FBI - quit getting so damned twacked out!"
When you're really high on meth or when you've been awake so long smoking dope that you're totally outta there! My friend was so twacked out on dope he thought that I was a cop.
I can't understand what the fuck you're saying cuz you're talking 100mph you're so twacked out.
I was so twacked out I thought there were undercover narcotics agents in the vanparked across the street.
Being twacked out is when you're on tweak and you're freaking out. Tweak is also known as ice, glass, crank, or most commonly, crystal methamphetamine.
Person A: "Dude, chill out!"
Person B: "Man, I'm totally twacked out." (Sitting there, picking at his skin/looking out the blinds/rocking back and forth)