Thirstiest (root word: Thirsty): The slutiest of sluts, to be thirsty is to be in need of a baller or a male/female with money to quench your desires. Thirstiest is to be the creme de la creme of whores, in appearance and attitude... WATCH OUT FOR THESE HOES! LOL
Man I saw the #thirstiest chicks out downtown Detroit tonight WTF is goin on??
A thirstbuster run is when one or multiple people at usually late / random hours get the sudden urge to travel to the circle-K convenience store and buy and consume thirstbusters, cheap 44 ounce sodas.
12:00 A.M, two people zoned out on the couch.
Person 1:"I'm in the mood for a thirstbuster, wanna make a thirstbuster run?"
Person 2:"Sure"