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twenty-first appendage 

This is a sly reference to and synonym for the penis or cock. For males adding the penis to the 10 fingers and 10 toes makes 21 appendages. Use this if you want to sound intelligent or don't want stupid or younger people to know what you are talking about.
I'm in the process of writing an epic poem about the love between me and my twenty-first appendage.

Twenty-First Century Gatsby 

Someone wealthy who throws parties like Gatsby today but with all the technology and fun that was around in the 20s and with the new culture.
Yeah he's the Twenty-First Century Gatsby.

twentyfirst base 

When you browse and masturbate to every base definition on urban dictionary
You: oh man I browsed every base definition on urban dictionary last night, I got all the way to twentyfirst base

Any rational human being: wow that's pretty sad bro
twentyfirst base by Thepeepeeman October 17, 2019