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Short for superhumans or "super-abled" in the "The Boys" comics & TV series; most of whom were created using a substance known as Compound-V.
Butcher : Supe-heroes, Supe-villains, Supe-terrorists, they are all the fockin same. Let's kill those motherfockin supe freaks!

Hughie : No they are not all the same. You don't know what you're talking about.

Butcher : Shut up, cunt! (*Long Stares). Boy, you have no idea, do ya?!
Supe by Halock September 19, 2020
"I's rather see Julia Stegner on that magazine cover. She's a supe."
supe by monz September 27, 2007
slang for supernatural creature including but not exclusive to werewolves, vampires or fey folk.
Supes are often misunderstood by humans because of their strange lifestyles.
supe by alliedoll42 December 18, 2012
To add aftermarket components to a vehicle to enhance acceleration, handling and performance. The root of the word is derived from superman (a figure synonymous with power/speed)
Yo mang my honda is suped to the tits!
-VW owns you you little bish!
supe by Nuttage April 21, 2004
what people do to inhance the speed/handeling of there vehicles on the street.
hey man didn't you say you'd supe up that moped some day?

hey i just suped up the motor on my moped so it flys now
supe by frankey August 1, 2003
shortened version of superior, used to describe anything that is cool or awesome.
That new album is supe. It is so much better than their last album.
supe by sazmatic September 6, 2008