Short for superhumans or "super-abled" in the "
The Boys" comics & TV series; most of whom were created using a
substance known as
Compound-V.
Butcher : Supe-heroes, Supe-villains, Supe-terrorists, they are all the fockin same. Let's kill those motherfockin supe freaks!
Hughie : No they are not all the same. You don't know what you're
talking about.
Butcher : Shut up, cunt! (*
Long Stares). Boy, you have no
idea, do ya?!