A concatenation of the words 'stupid' and 'fried'; When you are so mentally brain drained, that you cannot even properly say the phrase, 'stupid fried'; as in, 'My brain is so stupid fried...'
Mental exhaustion to the point where words start to slur together verbally and mentally.
"Today was a long day... My brain is stupifried. I can't even."
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.