Set-Out Share definition Flag A Set-Out is basically a hoe, whore, slut, etc. Someone who sets themself out to just about anybody. This term is used alot in Cleveland. "She could never be wifey, she a set-out." "She just gave me some head, she a set-out." Set-Out by Nazie November 8, 2006 0 0 Get merch Get the Set-Out mug. Buy Now — $32.95 See more merch