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Verb. To be in a situation where bodily fluids, typically but not necessarily semen, are in urgent need of cleaning up.
"He's got three stacks of Playboys in his room? Man. He's gonna need some tissues."

"Fuckin hell dude, I'm coming down with that killer cold that's been going around. I'm really gonna need some tissues."
by Danny Delinquent December 13, 2003
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