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1.)a miracle pill or all them bitches who are pms-ing...
2.)something you tell a guy to take when he is being a straight-up ass hole.
3.) something you wrap up and give to a girl who is a total bitch to show her how much of a bitch she is.
1.) crap, i havnt taken my midol yet, dont make me kill you!
2.)(to a guy) what the hell is your problem? take some midol, man. damn.
3.)have some midol you phsycotic bitch!
Midol by Shubalaskubba April 17, 2006
A woman's happy pill. She takes during her period, and the physical transformation from raving bitch-beast to human is simply astounding.
On-Period Woman: *random raving understood only by other menstruating bitch-beasts* *takes Midol* And now I'm human again! Thanks, Midol!
Midol by tenderlumpling August 2, 2008

midol suppository 

an imaginary pharmaceutical item that is used to imply a person is being a lame ass, pussy bitch, or suffering from PMS like symptoms.
Tyler: Man Jon is being a big pussy, he says he can't play Halo because his head hurts and he's tired.
Tate: Wow, sounds like he could use a midol suppository for sure.

American Midol 

The act of sitting your wife/girlfriend in front of the hit tv show "American Idol" for an uninterrupted hour of not being bitched at. The cable version of the pms medication, Midol.
Dude i gave my wife some american midol last night and i didn't have to talk or listen to her for an hour, it was better then sex
American Midol by Dylan684 August 11, 2010

Take a Midol 

"Take a Midol" is a disparaging phrase said to a woman who is behaving in a bitchy and confrontational fashion, as women are know to do when experiencing the symptoms of PMS. Sometimes said by a male, the phrase is more powerful when uttered by a female toward another female, as a strong complaint about the woman's behavior and/or attitude. (Midol is a commonly used over-the-counter medication marketed to women for the symptoms of PMS.)
Woman to woman: What is wrong with you? Stop being so upset and take a Midol!

Man to woman: Honey, please! Take a Midol before we have another domestic violence event in this house trailer!
Take a Midol by Rook's Buddy June 3, 2010

Pop a Midol and relax

A term used in response to a person that is overly hysterical and emotional, often about something very minor or pointless. It is meant to imply the person is emotionally unstable.

Midol is an analgesic typically used for menstrual cramping. While the medicines within can be used for other pains, Midol is typically marketed for such, so the fact that someone would imply one needs a Midol is that one is acting overly emotional like they are a hysterical woman in too much pain from cramps that they cannot think straight. Despite its gendered origins, it's often said to men, with the added implication that the man is completely unable to think rationally.
Bob: Did you hear what Trump did today? He called a female reporter a dumbass?

Jack: Bob, pop a Midol and relax.