When someone laughs ass and penis off.
The act of a person participating in humor while losing their bottom part of their rectum area, while also losing their genital area.
LMAPO IS LITERALLY LAUGHING MY ASS AND PENIS OFF!
by MeDM Sean June 10, 2020
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Person A: "im not sweating too much. unlike you lol. u insane sweater."

Person B: "I sweat so much because I'm hot."

Person A: "LMAPO"
by Glitterystar April 20, 2011
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hey george : that was so funny. lmapo
by getyastuff January 16, 2011
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lmapo stands for "laugh my ape pernice off"

say it when something is REALLY funny.
you:i just fell out of my coputer chair an knocked over a bowl of pretzels.

me:lmapo. that is funny
by Nebraska5849 May 6, 2008
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