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The opposite of hope. It is something that hope will always defeat.
It is also something Nagito Komaeda dislikes.
We'll never give in to your despair.
Despair by hopebagelko June 30, 2017
A word meaning the complete absense of hope, popularized among pop culture by the video game series Danganronpa.
Person: “I’ve sunken into despair; I dropped my donut.”

Despaphobia 

A fear of despacito 2 coming out
can also be used as a fear of despacito itself

despa - despacito
phobia - in fear of

phobiac - a person with a phobia
A person with this fear is called a despaphobiac
''Hey Shivam let's listen to despacito 2 when it's released''
Shivam: No I have despaphobia
''Ugh you despaphobiac.''
Despaphobia by Quivsy June 19, 2018

Despaphobia 

Luis Fonsi: Hey! Check out my new song, Despacito!
regular guy: no i have despaphobia
Despaphobia by Celiexal June 19, 2018

Mukuro Ikusaba, the 16th student, lying hidden somewhere in this school. The one they call the ultimate despair. Watch out for her. 

Mukuro Ikusaba, the 16th student, lying hidden somewhere in this school. The one they call the ultimate despair. Watch out for her.
Mukuro Ikusaba, the 16th student, lying hidden somewhere in this school. The one they call the ultimate despair. Watch out for her.

despafonsi 

a 3 ft tall bird with a body of a pigeon and the head of Luis Fonsi.
Has Despacito as a distress call and a mating call
"Hey look! a wild Despafonsi!"
despafonsi by Tsuenani? December 13, 2018