A crime committed against all that is good and holy by a woman when she kisses a man and has performed oral sex on another man within 24 hours. The man is then infected with Cockmouth, from which he can readily discern the taste of cock or ballsack, and in the most severe scenarios can taste the "taint salt."
"I think that girl at the party gave me cockmouth."
"I'm a horrible soulless bitch and blew this guy in the gas-station bathroom before making out with my boyfriend."
"That chick just blew me, and now she's giving her boyfriend Cockmouth!"
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.