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Meaning: What the fucks up?
Started from the Truth commercials that are against the tobacco companies.
Tobacco companies compared the addictivness of nicotine to jogging and m&m's. Whadafxup?
whadafxup by Alk3 Ownz U July 31, 2006
Idiotic anti-tobacco propaganda which uses scare tactics and idiot comparisons to spread irrational fears about tobacco. Hosted by some jackass who looks like he showers once a year and aspires to look as much like an insect as possible with his clothes and glasses.
went to a gun store to ask for light bullets, whadafxup?
whadafxup by robbles August 23, 2007

Whadafuck 

Exclamatory remark expressing confusion over or about something. Only to be used when slightly aggravated or agitated.
Somebody dents your car.
"Whadafuck!"
Whadafuck by Joe RS August 4, 2007
A morph of the phrase "What the f*ck is up?".
Ileena: Get awat form me skank!

Elisha: Wadafuxup with you today?!
wadafuxup by (Enter name here) March 13, 2008

Whadafaxmachine 

Used as a way to express strong feelings of anger, confusion, or enjoyment.
Dude1: This monkey is jacking it.

Dude2: Whadafaxmachine?!!?!?!?!?!?!?!
Whadafaxmachine by Phyrast August 3, 2007

Whadafuhuhwidah 

A perfectly appropriate way to say "what the F*$% is up with that" in public.
It's April and it's snowing... Again! Whadafuhuhwidah?
Whadafuhuhwidah by akbackstrom April 3, 2019