Being so irreversibly under the influence of alcohol that social ques and the surrounding environment no longer have any impact on a persons actions or decision making
An adult, most commonly a male, who has never fully developed or matured emotionally and is characterized by a low degree of self awareness, awkward interactions with other people, a lack of empathy and an inability to achieve intimacy.
Gary: "Ken, I hate to be the one to tell you this but Uncle Gilbert has cancer."
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.