Sheen Flu is when you're the victim of a massive and horrible hangover. It implies that you were partying like Charlie Sheenthe night before, and may be on the brink of death.
Guy 1: OH MY GOD, I AM SO SICK. I HAVE THE SWINE FLU! ZOMG!
Guy 2: No, you just have a case of the Sheep Flu
Guy 3: Oh No! I heard you can DIE from that.