An outspoken female Republican, in particular from the Trump Presidency era, who turns a blind eye to their party's misogynistic overtones.

The term is a reference to the novel and tv series "The Handmaid's Tale", in which the wife of the Commander, Serena Joy, actively fought for the totalitarian regime of Gilead, only to be considered inferior when the regime comes into play, due to her gender.
I can't believe the Serena Joys are supporting Trump and his continuous disrespect of women.
by Like.Wow.Totally.Yeah October 19, 2018
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A nickname for 45’s Supreme Court nominee, Amy Coney Barrett, due to her affiliation with People of Praise, a small religious group who refers to its women members as “handmaids,” thereby highlighting a similarity to Margaret Atwood’s “The Handmaid’s Tale” whose character Serena Joy is equally diabolical in her anti-feminist agenda.
Serena Joy Barrett is the perfect high ranking intellectual vessel to make women believe they are being elevated and empowered when exactly the contrary is true.
by Dr Bunnygirl September 27, 2020
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A term for the feeling of going back and forth between liking/loving and disliking/hating a character due to their actions.

The term originated from when me and my friends watched "The Handmaid's Tale". Like wtf Serena?
"For fuck sake, Serena! You took one step forward and now you take five steps back! Like, what the fuck?! It's literally been five minutes! I was starting to like you again!"

"Yeah, that's the Serena Joy effect for you."
by blue the herbo February 18, 2021
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