as others have stated: something has angered, upset, annoyed, aroused you
this is more of a side note on origin - I suspect the phrase was a spontaneous misquote of a line from the Weezer song "Say It Ain't So" ("...flip on the telly/ wrestle with Jimmy...")

man, that pic was disgusting.
yeah, that one rustled my jimmies

rustled my jimmies by kingprout1 September 2, 2015

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Are your jimmies rustled?

jimmies – feelings / thoughts / ego
rustled – hurt / disturbed
unrustled – peaceful / calm

As per Know Your Meme, the expression originated from 4chan in late 2010, and is used by trolls to "convey feelings of discontent or discomfort in response to someone else’s post in imageboards and discussion forums".

The expression is an alternate form of "u mad bro?".

Victim: What the heck is your problem!?
Troll: Are your jimmies rustled?
Victim: ...What is this I don't even—
Troll: *trollface*

Are your jimmies rustled? by AgentRev December 18, 2012

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Rump rustled

Being so upset and mad that you no longer know what to do or to say

He was so rump rustled because he got proven wrong by the whole class

Rump rustled by qwert1357 April 13, 2015

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Super Rustler

IRL bully victim who says people should get cancer over the internet because they have no social interaction irl because his dad beats him/her and molests him/her in the shower
We are super rustlers and we don't care we are irl bully victims on twitter

Example
Olly: Let's rustle tonight
RacistBaller: Of course my LORD anything for you
NeyBaertra: yes haha 9/11 cancer jimmies imo

rest of twitter with functioning brain cells and relevant cognition
super rustlers are the worst thing since sliced bread

Super Rustler by LADSfromTwitter October 16, 2014