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An annual spring event at Radford University involving free live bands and food where students (and some faculty) begin drinking at 12pm on thursday, drink straight through the weekend, and stop drinking at 8am monday. Some years they even have to bring in the National Guard to control the drunken insanity.
"it's 10am on a friday and you're drunk already?!?"
"IT'S QUADFEST!"
quadfest by unknown April 16, 2005

myspace quadfecta

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Quadfecta 

When Mario Kart is being played, and a player gets last place all four races.
Player 1: Jim got the quadfecta!
Quadfecta by Iced_ September 1, 2017
A loose flap of skin hanging at the back of the scrotum.
Doctor, please remove this quaddie from the back of my balls.
Quaddie by Dikkzor March 27, 2015

quadfecta 

A legendary beirut/beer pong shot that lands on the tops of four cups simultaneously. Considered the rarest shot in the game, topping even the trifecta, 2-cup knockover-and-sink, and simultaneous 6-cup game-ending double bounce-in. Counts as 4 cups and has never happened in recorded history of the game, despite being theoretically possible.

So rare for the following reasons:
1) Only possible with smaller-than-average cups.
2) Only possible when cups are arranged in a perfect square formation (not possible in a standard game).
3) The physics of it happening are similar to those of the trifecta, which almost never happens in itself.
Witnessing Dan's game-ending quadfecta in the semifinals of the Theta Delt beirut tournament was a thing of beauty comparable to seeing the face of God Himself smiling down on you from the heavens.
quadfecta by Nicholas D December 24, 2007

Quadfecta 

A woman who is an impossible combination of smart, cool, funny, and beautiful.
Alicia is smart, gorgeous, funny and cool... The legendary Quadfecta.
Quadfecta by Haggernaut August 19, 2012