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An extremely vulgar phrase in Italian. Putana means slut/whore/prostitute. The Madonna is Mary, the mother of Jesus. "Madonna" is sometimes translated as "mother of God."

If you say this phrase, you're basically calling Jesus's mom a whore.
Uomo 1: "Mia moglie รจ incinta da un altro uomo"
Uomo 2: "Putana Madonna! Crepi!"
by diovero August 16, 2007
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