Based off the late football player Brian Piccolo who died of cancer, "get piccolo" means to get cancer and die. A phrase invented by Youtuber Elpresador. Used as an insult.
Ginnygoat: Fuck you Pres, your vids are shit. Stop blaming the game, You just suck at COD.
Elpresador: Fuck you ginnygoat. You know and I know I'm the best COD player ever. Get piccolo motherfucker
Piolo comes from the word Paul next to the name of St. Paul of Vatican. Holliness and has fear to god. He embraces nature health and empower human skills through programs. Piolo is loved and grateful in everything came up on him.
The act of raising/mentoring your arch enemy´s child as your own after defeating or killing him/her in glorious combat. Coming from the plot devise in Akira Toriyama´s popular Dragon Ball Z anime.
In the Kenneth Branagh´s Marvel Comics inspired movie Thor (2011), the main antagonist Loki is motivated to usurp Odin after realizing that he had been piccolo´d by him.