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The look on someone's face after returning from a long night of partying and bar crawling. This night usually consists of an immense amount of cheap alcohol (and most likely, drugs as well).
Dude, did you just get back from the bar? You look picasso'd!
Picasso'd by Micah Jesse February 14, 2006

Picasso'd the toilet 

When your poop hits the toilet at a high velocity or has a consistancy that makes it sticks a pattern to the toulet bowl even after a flush, as if painting like the artist Picasso.
Hey man, I'd wait at least 10 minutes before using the bathroom, I just picasso'd the toilet.
Picasso'd the toilet by DocAshe October 6, 2011

The Picasso Defense 

When bad visual artists (the illustrative kind) drop Pablo Picasso's name in the middle of a discussion to defend their lack of skill. The defense is usually made after people suggest problem areas the artists may want to work on- especially anatomy- and typically comes coupled with a phrase like "it's my style." Think of it like Godwin's Law, but for artists.
Artist A: You have some problems with proportions and either draw hands backwards or hide them in characters' pockets/behind their backs. I suggest studying from real people for a while, and even though it sucks, try not to hide them as much. You won't get better at drawing hands if you avoid them. The rest of your stuff looks really good, though. I like the way you shade hair. Great work!

Artist B: Fuck you motherfucker. You think you can tell me what to fucking do?! Did you think for a second that maybe there's nothing wrong with my anatomy? Maybe you're fucking blind but people mess with proportions ALL THE TIME. Not everyone draws realism you dumb shit. My styles just different from what you think is PERFECT AND SUPER WONDERFUL DESU! Pablo Picasso's anatomy wasn't perfect either. He drew ugly abstract shit all the time. Why aren't you complaining about how fucked up HIS anatomy was, huh?! HUH?!!! GO FUCK YOURSELF!!

Artist A: Pablo Picasso mastered realism when he was a teenager. He didn't make abstract things because he didn't know how to draw people. He drew them that way purposely after learning anatomy. You have to know the rules before you can break them. Stop using the Picasso defense to justify your flaws. Backwards thumbs and hiding hands isn't a style.
The Picasso Defense by Jakkrobbit August 31, 2013

dirty Picasso

When, during the act of anal intercourse, the male removes his penis from his parter's anus and smears feces & ejaculates on the partner's back, thereby creating a masterful work of art.
"I've never gotten the dirty Picasso, but I hear it's a pain in the ass to wash off your back."

Pablo Diego José Francisco de Paula Juan Nepomuceno María de los Remedios Cipriano de la Santísima Trinidad Clito Ruiz y Picasso

Pablo Diego José Francisco de Paula Juan Nepomuceno María de los Remedios Cipriano de la Santísima Trinidad Clito Ruiz y Picasso is the emoticon face that visited the LGBTQ+ scratch studio (AKA the Gaehive) in June of 2021. He seems to use he/they pronouns. This is Pablo: (͠≖ ͜ʖ͠≖)
Pablo Diego José Francisco de Paula Juan Nepomuceno María de los Remedios Cipriano de la Santísima Trinidad Clito Ruiz y Picasso is our god.

do a picasso 

When you have taken so many drugs your mouth is at the other side of your face to your eyes
I'm going to do a picasso tonight, my face will be a picture.
do a picasso by bexscooper August 4, 2015