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This is a acronym that stands for "Old Fashion Faggot".
O.F.F by Pie Between Thighs February 27, 2019
An O.F.F. or an off is an "overly flirtatious friend." Usually, this would coincide with people known to be players, or just straight up unaware that they're affecting you in such a way. They may result in heartbreak, emotional distress, happiness if you're looking for that special attention, and cringe-worthy pick-up lines.
Be careful about having feelings for Bob. I heard he's been an O.F.F.
O.F.F. by mandm45 November 14, 2016

O.F.F.S. 

O.F.F.S. OH for fuck sake! My dog shit on the carpet, again!
O.F.F.S. by offs August 14, 2014

Going O-F-F 

adj. Firing. Awesome. Great. Huge.
(used in surf slang)
"The waves were Going O-F-F.
Going O-F-F by skullcap January 13, 2004

G.O.F.F. 

"Good Old Fashioned Fun"
doing childish things like playing at a park or going to a movie or just sitting outside. Usually done while under the influence of marijuana or alcohol.
Marsh: Hey man, wanna have some G.O.F.F. today?
Lonnie: Yeah dude, we should have some G.O.F.F. at the park by playing some whiffle ball.
G.O.F.F. by Fundue May 5, 2008

I.F.O.F.F. 

International Federation Of Father Fuckers.
See Fatherfucker
People into Rap/Hip Hop seem to get really annoyed when someone says Fatherfucker. Not any more offensive than the term Motherfucker
Are the Mother Fuckers ready for the Father Fuckers - a line from the Album "FatherFucker" by Peaches.
I.F.O.F.F. by Spotsaneed June 14, 2004