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Laugh out loud so hard you fall off the chair and hit your head on the way down to the floor."
Guy - Hey beautiful, where were you all night?
Girl - Sorry, got busy on the cell.
Guy - You won't believe this - I got bored and added your Mom as a Facebook friend; and then she tried to chat up for some Cyber Sex.
Girl - wtf; you bastard; I'll cut your nuts off.
Guy - Aww baby. I was just kidding. But damn, I got you so good. LOLzels.
Girl - You better be telling the truth or I will cut you.
Guy - I am baby, I am. I was all just a joke.
LOLzels by tony1111 December 20, 2009
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lolzersize 

When one laughs with enough force to induce sweat, tears, urine or physical pain.
Holy shit i just lolzersized so hard my pants are wet.
lolzersize by Zarbongliaboltsk October 28, 2010
Related Words
LAHLZUHERZ (lahl-zehr-z):
an exclamation used to express one's comic appreciation of something, generally a recent action or intangible idea.

Other acceptable spellings:
1. lahlzers
2. lolzerz(s)
3. LOLzerz(s)

Note
It is appropriate to occasionally drop the s or z at the end to lessen the intensity of the expression. The final degree of lessening the level of emotion (from "lolzer") is simply "lolz(s)." this is typically used to display almost a level of neutrality towards the previous comment, almost as if to simply acknowledge that it was said.
"I just shot myself in the face."
"Lolzers"

vs.

"Ouch I just stubbed my toe"
"Lolzer"

vs.

"Too bad we missed the game"
"Lolz"
lolzers by James and Will March 16, 2008
Ghetto are of Birmingham. Home to gangs, murders and crime.
Lozzels is a ghetto!
Lozzels by Ashley Blake-Moore January 5, 2008
when something is so funny that you need to pee
omg hahahah lolzers that is so funny I need to pee
lolzers by Sissy 🙌 July 13, 2020
combining the term lol (laugh out loud) with wowzers
Someguy: man last night was totally bitching!
Somegirl: yeah if u call having a 2pump chump as a fuck buddy bitching.
Somedudelistening: lolzers!
lolzers by iLLNiSS May 8, 2006

lolzelda 

Another word of utter randomness originating from the acronym "lol" which stands for Laugh Out Loud. Lol is often added with a z at the end, such as "lolz."
Jenerate: lolzelda, what are you doing in my bathtub?
Danaconda: Masturbating. Wanna join?
lolzelda by Jenerate Yurself October 26, 2008