L.I.S 

lazy indian syndrome (not the ones that work on xbox, but the native americans.), when someone is 45% or more native American and won't do any work.

"Man! That guy outside the convenience store with the brown bag must be a major L.I.S sufferer "

L.I.S by just stubbin January 5, 2010

L.I.S 

L.I.S is a really good Minecraft Bedrock game that is hosted by Geckoimpossible.

"Who L.I.S is so fun"
"I know it's a really good Minecraft game!"

L.I.S by Geckoimpossible May 2, 2022

L.I.S.A. 

L = Logical
I = Intelligent
S = System
A = Administration

This individual only communicates through email, her existence is questionable, possibly a software system.

"Yo man can you run this by the L.I.S.A.?"
"I heard she's not even a real person"
"Swerve"

L.I.S.A. by TrapPharaohRogerBrown September 14, 2018

l.i.s.w.a.g.t.h. 

life is shitty, we all go to hell

Me: "l.i.s.w.a.g.t.h."

Her: "for fuck sakes stop being a depressed bitch"

l.i.s.w.a.g.t.h. by depressed lover May 22, 2020

C.L.I.T.O.R.I.S.

The Committee for the Liberation and Integration of Terrifying Organisms and their Rehabilitation Into Society

Red Dwarf - Polymorph. "I think we're all beginning to lose sight of the real issue here, which is: what are we going to call ourselves? I think it comes down to a choice between "The League Against Salivating Monsters" or, my own personal preference, which is "The Committee for the Liberation and Integration of Terrifying Organisms and their Rehabilitation Into Society." One drawback with that--the abbreviation is C.L.I.T.O.R.I.S.", Rimmer.

C.L.I.T.O.R.I.S. by Absolut Russia November 20, 2006

I.C.Y.D.K.B.I.C.B.Y.A.I.W.B.L.I.I.S.T.I.C.L.T.L.W.Y 

ABBREVIATION FOR IN CASE YOU DIDNT KNOW BABY IM CRAZY BOUT YOU AND I WOULD BE LYIN IF I SAID THAT I COULD LIVE THIS LIFE WITHOUT YOU

*Text from signjficant other *: I.C.Y.D.K.B.I.C.B.Y.A.I.W.B.L.I.I.S.T.I.C.L.T.L.W.Y

I.C.Y.D.K.B.I.C.B.Y.A.I.W.B.L.I.I.S.T.I.C.L.T.L.W.Y by swanrose365 July 7, 2021

C.L.I.S 

an acronym for the Coalition to Legalize Incestual Sodemy. this group is found all across the southern untied states

Me and my mom just joined C.L.I.S becuase it stands for our beliefs.

C.L.I.S by coon jigger June 18, 2008