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When you are a fairly attractive person but you can't seem to maintain a relationship regardless of how attractive you are.
SUE: My boyfriend broke up with me. I thought we had a great relationship. I don't understand why I can't manage to stay in a good relationship.

LORI: got Jennifer Aniston Syndrome.
by not4uboy August 20, 2010
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When you seem to not age at all or even age backwards. Usually by way of plastic surgery.
Rebecca: Wow! You actually look younger than the last time I saw you!

Sheryl: Well, I did get diagnosed with Jennifer Aniston Syndrome
by HorseJerky1776 January 05, 2020
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