When you are a fairly attractive person but you can't seem to maintain a relationship regardless of how attractive you are.
SUE: My boyfriend broke up with me. I thought we had a great relationship. I don't understand why I can't manage to stay in a good relationship.
LORI: Girl...you got Jennifer Aniston Syndrome.
LORI: Girl...you got Jennifer Aniston Syndrome.
by not4uboy August 20, 2010

Rebecca: Wow! You actually look younger than the last time I saw you!
Sheryl: Well, I did get diagnosed with Jennifer Aniston Syndrome
Sheryl: Well, I did get diagnosed with Jennifer Aniston Syndrome
by HorseJerky1776 January 05, 2020
