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holy moses 

a phrase that can be used interchangeably with "holy crap" or "holy Lord." usually exclamatory.

originally coined, to my knowledge, by this dude I know named Zac.
Dude #1: Look! That one dog is raping that other dog like in prison!
Dude #2: Holy moses!
holy moses by conor March 3, 2005

Holy Moses 

When something so wild happens even the brother Moses couldn’t comprehend it
Me: yo you see that big booty girly ask out that one mans I’ve never even heard of?

George: holy Moses man how the hell did that happen
Holy Moses by jerafe May 30, 2019

Holy Moses Mother of Pearl 

Holy Moses Mother of Pearl is something you would yell instead of swearing when your in the company of small children and the elderly and something bad has happened.
On the way home from Chuck-E-Cheese Pizza, Ryan's friend started to feel sick and to his moms surprise Ryan's friend Jesse vomited hitting her in the back of her head! With vomit running down her back she almost dropped the "F" bomb and instead shouted, "Holy Moses Mother of Pearl!" "Did you just recycle pizza in my hair?"