Holy Moses Mother of Pearl is something you would yell instead of swearing when your in the company of small children and the elderly and something bad has happened.
On the way home from Chuck-E-Cheese Pizza, Ryan's friend started to feel sick and to his moms surprise Ryan's friend Jesse vomited hitting her in the back of her head! With vomit running down her back she almost dropped the "F" bomb and instead shouted, "Holy Moses Mother of Pearl!" "Did you just recycle pizza in my hair?"
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.