Used as a term of endearment towards a friend, but that is still on the mean side. Used to call a friends a hoe or bitch because they did something but is meant to say it in a more friendly or playful way and not a I'm gonna kick your ass kinda way. It has a wider range of uses.
Sammi just got the number of a guy you were checking out at the party, she's such a hoeknuckle. Or. You hoeknuckle !!!
Ruler of Lake Titicaca. Rumored to have a bunghole that gets very angry if it does not receive toilet paper. Cornholio the Great is often seen walking around with his shirt over his head and his hands in the air, chanting songs about his power, and his bunghole.
"I am Cornholio! You do not want to face the wrath of my bunghole, for I need TP!"
Butthead: Shut up, Beavis! (uh huh huh huh)
Beavis: Um, okay. (heh heh heh heh).