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detonation of the dick 

The eventual side effect of ridiculously over-prescribed medications.
My doctor prescribed me FuckYouNoll and warned me of the side effect I'll lose my cock to Detonation Of The Dick.

Domepiece Detonation 

When you take any alcoholic carbonated beverage and shake it to build pressure, smash it off your forehead and continue to drink it shotgun style
Me: Bro did you see what Fisher did last night? We was so drunk he did 3 domepiece detonations
Domepiece Detonation by Qweeeem February 8, 2018

nuclear ass detonation 

a gigantic ass explosion (which see). Not just explosive but NUCLEAR. Chars the ass releasing it, resulting in painful dumps for days following. Usually the result of alcohol and some type of spicy food. The fumes blind anyone within the confines of the restroom.
"Dude, i had beer and taco bell last night....shit...this morning i had a nuclear ass detonation"

Premature Detonation 

A unique phenomena among would be suicide bombers where their explosives detonate prematurely.
Palestinians sometimes refer to this as a "work accident".
Due to Ahmed's premature detonation he was sent to the virgins early.
Premature Detonation by capt diggs November 19, 2011

internal detonation 

When squeezing a spot and all the hall marks of it popping are there, i.e pain and a crunching sensation/noise, but any puss or fluids havent been ejected from the body but have burst under the skin and are still internal.
"I had a well painfull spot the other day, but it didnt burst properly, just internal detonation"

Cock and Ball Detonation (CBD) 

Cock and ball detonation (CBD) is a sexual activity involving application of explosives to the male genitals. This may involve directly applying plastic explosives, dynamite in the butt or taped to the shaft, black cats in the urethra, application of blast tape to the balls, incendiary rounds, IDEs, flash powder, PENT, cherry bombs attached to the balls, or putting your penis in tannerite.
Damn Cock and Ball Detonation (CBD) is hot, I wanna try it with my friend.